Mouse
Cripto (Tdgf1) null mutants
The Cripto +/- mice are healthy and fertile. The Cripto -/- mutants dye during embryo development at about 9.0 dpc, due to gastrulation failure
Cer1; Cripto double mutants
Cer1;Cripto compound mutants recover the orientation of the A–P axis and most of the subsequent gastrulation processes, which are severely impaired in the Cripto null mutants. Moreover, a subset of Cer1−/−;Cripto−/− embryos show the formation of a double axis
