Model System - AD 255
Deletion mutant, known as Delta halo, lacking its endogenous Odorant Receptor genes, OR22a and OR22b.
Category:
Invertebrates
/
Drosophila melanogaster
Arrival or creation date: Mar 14, 2011
Last revision: Dec 17, 2014
Author(s):
M. Welte, Dobritsa AA, van der Goes van Naters W, Warr CG, Steinbrecht RA, Carlson JR
Contact
Name: F. Anna Digilio
Address: Institute of Biosciences and BioResources - CNR, Via P. Castellino 111, 80131 Naples, Italy
Phone: +39 081 6132430
Email: anna.digilio@ibbr.cnr.it
Genotype: w; Dhalo/CyO;Dr/TM3,Sb.
Origin: Carlson JR
Description
Due a sinthethic deletion of the Odorant Receptors 22a and 22b, this strain contains a mutant neuron lacking odor response, known as empty neuron. Using the UAS/GAL4 system, a heterologous Odorant Receptor can be introduced specifically in the empty neuron and studied. In our laboratory, we used this strain to express the heterologous AalOR2 (Aedes albopictus Odorant Receptor 2) gene, demostrating that this OR is narrowly tuned to indole, and inhibited by (-)-menthone.
Quality validation:
Yes
Validation info
The Model System has been both published in peer-reviewed journals and used to obtain data reported in a peer-reviewed journal.
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