The book “Mathematical Models in Biology” presents an exciting collection of contributions based on the workshop “Bringing Maths to Life” held October 27-29, 2014 in Naples, Italy.  The state-of-the art research in biology and the statistical and analytical challenges facing huge masses of data collection are treated in this work. Specific topics explored in depth surround the sessions and special invited sessions of the workshop and include genetic variability via differential expression, molecular dynamics and modeling, complex biological systems viewed from quantitative models, and microscopy images processing, to name several. One chapter reports the application of statistics-based Design of Experiments methodology to PEI toxicity assay on neural progenitor cells by Mancinelli and coworkers. In the chapter are reported general principles of DoE methodology, a compartison between DoE and the classical One Factor at a Time (OFAT) method, and the study of the effect of PEI trasfectant on cell viability and its interaction with other factors involved such as DNA and cell density.