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Gint4.T

Gint4.T

Gint4.T, a nuclease resistant RNAaptamer, is able to specifically bind to the human PDGFR ectodomain (Kd, 9.6 nM) causing a strong inhibition of ligand-dependent receptor activation and of downstream signaling in cell lines and primary cultures of human glioblastoma cells. It drastically inhibits cell migration and proliferation, induces differentiation, and blocks tumor growth in vivo. Gint4.T aptamer prevents PDGFR heterodimerization with and resultant transactivation of epidermal growth factor receptor (EGFR).

Category: modified RNA  - 

CL4

CL4

CL4 is a nuclease resistant RNA-aptamer that specifically binds to EGFR with a binding constant of 10 nM. When applied to EGFR-expressing cancer cells the aptamer inhibits EGFR-mediated signal pathways causing selective cell death. Furthermore, at low doses it induces apoptosis even of cells that are resistant to the most frequently used EGFR-inhibitors, such as gefitinib and cetuximab, and inhibits tumor growth in a mouse xenograft model of human non-small-cell lung cancer (NSCLC). Interestingly, combined treatment with cetuximab and the aptamer shows clear synergy in inducing apoptosis in vitro and in vivo.

Category: modified RNA  - 

GL21.T

GL21.T

GL21.T binds the extracellular domain of human Axl receptor tyrosine kinase. GL21.T blocked Axl-dependent transducing events in vitro, cell migration and invasion, as well as in vivo lung tumor formation in mice xenografts. Furthermore, because of its ability to rapidly internalize within Axl-positive target cells it is a highly promising candidate as cargo for tissue specific internalization. GL21.T represents a promising therapeutic molecule for Axl-dependent cancers whose importance is highlighted by the paucity of available Axl-specific inhibitory molecules.

Category: modified RNA

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